This can often come off as a bit hypocritical, particularly when dealing with speculative fiction, as you get an Anvilicious message of "everything we have so far is good, but we should stop now."
Sometimes the theme is softened by the presence of The Professor among the heroes who represents a more reasonable take on the science involved. In the end, the scientist will be destroyed by his own creation, the heroes will be proven right, and through their efforts the world will be saved from the horror of science. The antagonist (almost always either corporate or military/government scientists - and not hot) refuses to believe that his work could be so badly flawed and/or immoral, or simply doesn't care about who gets hurt by it, insisting that the research is For Science!! They will generally use their influence with the government to make life difficult for the heroes this can include trying to have them arrested and/or otherwise silenced, often leading to a shoot-out, jail break, or Chase Scene.
The heroes typically discover the side-effects of the research and investigate, discover what's going on, and try to stop it. The typical theme is that some sort of advanced scientific research has Gone Horribly Wrong, creating a monster, causing an impending natural disaster and/or a massive government cover-up. Whether it is because they perceive science as cold and emotionless, or because they just disliked science and embraced literature after failing math in high school, luddism is an awfully common philosophy in the arts community.
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